Water → Methyl 4-(2-phenylsulfonylamino-5-chlorophenylaminocarbonyl)benzoate

HRID 1006536ノート

反応式

HRID 1006536 の反応式
[C:1]1([S:7]([NH:10][C:11]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:12]=2[NH2:13])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.[CH3:25][O:26][C:27]([C:29]1[CH:37]=[CH:36][C:32]([C:33](Cl)=[O:34])=[CH:31][CH:30]=1)=[O:28].O>C(Cl)Cl>[C:1]1([S:7]([NH:10][C:11]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:12]=2[NH:13][C:33]([C:32]2[CH:36]=[CH:37][C:29]([C:27]([O:26][CH3:25])=[O:28])=[CH:30][CH:31]=2)=[O:34])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 81850Methyl 4-(chlorocarbonyl)benzoateHCID 130413992-Phenylsulfonylamino-5-chloroaniline

生成物 1

HCID 12017672Methyl 4-(2-phenylsulfonylamino-5-chlorophenylaminocarbonyl)benzoate収率 79.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-phenylsulfonylamino-5-chloroaniline (90 mg; prepared in Reference Example 12.) and pyridine (0.05 ml) in methylene chloride (5 ml), 4-methoxycarbonylbenzoic acid chloride (70 mg) was added at room temperature in a stream of argon. The mixture was stirred for 6 hours. After the termination of reaction, water was added to the reaction mixture. The mixture was extracted with ethyl acetate. The organic layer was washed, dried over and concentrated under the reduced pressure. The residue was purified by the recrystallization from AcOEt-hexane mixture solvent to give the title compound (112 mg) having the following physical data.

後処理

  1. additionwas added to the reaction mixture
  2. extractionThe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed
  4. customdried over and
  5. concentrationconcentrated under the reduced pressure
  6. customThe residue was purified by the recrystallization from AcOEt-hexane mixture solvent

出典と根拠

ORDレコード
ord-a677d512286b423994c01bc2cda270f2
出典データセット
uspto-grants-2004_09
特許番号
US06790866B2

反応ノート

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