2-nitro-5-trifluoromethylphenyl Methoxymethyl Ether → 2-amino-5-trifluoromethylphenyl Methoxymethyl Ether
反応式
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:6]=1[N+:15]([O-])=O>CO.[Pd]>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:8]=[CH:7][C:6]=1[NH2:15]参加物
4
実験手順
To a solution of 2-nitro-5-trifluoromethylphenyl methoxymethyl ether (353 mg; prepared in Reference Example 19.) in MeOH (3.5 ml), 10% Pd—C (30 mg) was added in a stream of argon. The mixture was stirred vigorously at room temperature under hydrogen atmosphere. The reaction mixture was filtered through celite and concentrated under the reduced pressure to give the title compound (313 mg) having the following physical data.
後処理
- filtrationThe reaction mixture was filtered through celite
- concentrationconcentrated under the reduced pressure
出典と根拠
- ORDレコード
- ord-896df9e5cdeb4ef8881b9d572933c779
- 出典データセット
- uspto-grants-2004_09
- 特許番号
- US06790866B2
反応ノート
読み込み中…