Potassium Cyanide → 2-(2-Bromo-3-methylphenyl)acetonitrile

HRID 1006697

反応式

HRID 1006697 の反応式
[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[C-:11]#[N:12].[K+]>CN(C)C=O>[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][C:11]#[N:12]

参加物

4

反応物 2

HCID 9032Potassium CyanideHCID 109343202-Bromo-1-(bromomethyl)-3-methylbenzene

生成物 1

HCID 226726132-(2-Bromo-3-methylphenyl)acetonitrile収率 44.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

A mixture of 2-brom-3-methylbenzylbromide (25 g, 0.095 mol) and potassium cyanide (16 g, 0.25 mol) in dimethylformamide (100 ml) was stirred at 90° C. for 20 h. The solvent was evaporated under reduced pressure and to the residue were added toluene and water. The organic layer was separated washed with water, separated and evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel using methylene chloride as eluent gave 8.8 g (44%) of the title compound.

後処理

  1. customThe solvent was evaporated under reduced pressure and to the residue
  2. additionwere added toluene and water
  3. customThe organic layer was separated
  4. washwashed with water
  5. customseparated
  6. customevaporated under reduced pressure
  7. customPurification of the residue by column chromatography on silica gel

出典と根拠

ORDレコード
ord-9ba3ef7949d34f6181be2d166926885e
出典データセット
uspto-grants-2004_09
特許番号
US06790960B2

関連ノート

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