3,4-Dimethoxybenzonitrile → 3,4-Dihydroxybenzonitrile

HRID 1006703

反応式

HRID 1006703 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11]C)[C:6]#[N:7].COC1C=C(C=CC=1O)C#N.[Br-].[Li+]>>[OH:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[OH:11])[C:6]#[N:7]

参加物

4

反応物 3

HCID 748423,4-DimethoxybenzonitrileHCID 781354-Hydroxy-3-methoxybenzonitrileHCID 82050Lithium Bromide

生成物 1

HCID 870653,4-Dihydroxybenzonitrile収率 65%

実験手順

The preparation was carried out according to the process of Example 2a except that 3,4-Dimethoxybenzonitrile was used as the starting material instead of 3-methoxy-4-hydroxybenzonitrile, and 2-fold of lithium bromide (162.6 g, 1.88 mole) were added to form the reaction mixture. 3,4-Dihydroxybenzonitrile was obtained as a white solid with a yield of 65% and a purity of greater than 98% as indicated by HPLC analysis.

後処理

  1. customto form the reaction mixture

出典と根拠

ORDレコード
ord-70827bf2c6ba4f4b8a321be70726b5ad
出典データセット
uspto-grants-2004_09
特許番号
US06790977B2

関連ノート

読み込み中…