Water → Isopropyl purine
反応式
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2C(C)C)=[C:4](NCC2C=CC(OC)=CC=2)[N:3]=1.[H-].[Na+].I[CH:27]([CH3:29])[CH3:28].O>CN(C=O)C>[CH:27]([C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[CH:4][N:3]=1)([CH3:29])[CH3:28]参加物
6
実験手順
Preparation of 2-chloro-6-(4-methoxybenzylamino)-9-isopropylpurine (2) 2-chloro-6-(4-methoxybenzylamino)purine was suspended in dry DMF (5 ml) and treated with sodium hydride, 60% dispersion (82 mg, 2.06 mmol). The suspension was stirred for 30 min over which time it became a clear yellow/green solution. 2-Iodopropane (0.280 mL, 1.7 eq.) was added over 5 min and the resultant solution stirred for 2 days. Water was added and the solution and extracted with ethyl acetate. The organic layer was evaporated to give the product isopropyl purine (Yield=508 mg, 89%).
後処理
- extractionthe solution and extracted with ethyl acetate
- customThe organic layer was evaporated
出典と根拠
- ORDレコード
- ord-196f4ce80fe6436488f0ed0c557f72f3
- 出典データセット
- uspto-grants-2004_09
- 特許番号
- US06794390B2
反応ノート
読み込み中…