Trifluoroacetic acid → HCID 178511291、化合物

反応式

C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([C@@H:13]3[CH2:15][C@H:14]3[C:16]#[N:17])[N:10]=[CH:9]2)C=CC=CC=1.[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[C:16]([C@@H:14]1[CH2:15][C@H:13]1[C:11]1[N:10]=[CH:9][NH:8][CH:12]=1)#[N:17]

参加物

反応物 2

HCID 6422Trifluoroacetic acid

HCID 69872359HCID 69872359、化合物

生成物 1

HCID 178511291HCID 178511291、化合物収率 55%

実験手順

A mixture of N-triphenylmethyl-4-(trans-2-cyano-cyclopropyl)imidazole (200 mg, 0.54 mmol) and trifluoroacetic acid (TFA) (10 mL) was stirred at room temperature for 1-3 hours. The TFA was evaporated under reduced pressure. The resulting mixture was diluted with distilled water (5 mL) and extracted with ether (3×15 mL). The aqueous layer was lyophilized to give the product as a solid (73 mg, 55% yield).

後処理

customThe TFA was evaporated under reduced pressure
additionThe resulting mixture was diluted with distilled water (5 mL)
extractionextracted with ether (3×15 mL)

出典と根拠

ORDレコード: ord-53478d981d1e4cc49a574fc033ee6e61
出典データセット: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06794405B2

反応ノート

読み込み中…

参加物