Triphenylphosphine → 4-Aminofuro[3,2-c]pyridine-2-carbonitrile
反応式
I[C:2]1[O:10][C:9]2[CH:8]=[CH:7][N:6]=[C:5]([NH2:11])[C:4]=2[CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[NH2:31][C:32]1C2C(=CC=C(C#N)C=2)C=CN=1>CN1CCCC1=O.[C-]#N.[Zn+2].[C-]#N.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[NH2:11][C:5]1[C:4]2[CH:3]=[C:2]([C:32]#[N:31])[O:10][C:9]=2[CH:8]=[CH:7][N:6]=1参加物
7
実験手順
This compound was prepared from 2-iodo-furo[3,2-c]pyridin-4-ylamine (5.2 g), zinc cyanide (3.6 g), triphenylphosphine (2.1 g) and palladium acetate (1.8 g) in 75 mL of N-methyl-pyrrolidone using the procedure described for 1-amino-isoquinoline-7-carbonitrile. Yield: 2.0 g (64%); yellow solid; m.p. 280° C. (decomp.).
出典と根拠
- ORDレコード
- ord-02c74e5de15a42509fc99605080e48f0
- 出典データセット
- uspto-grants-2004_09
- 特許番号
- US06797710B2
反応ノート
読み込み中…