Trifluoroacetic acid → n-(1-Amino-isoquinolin-6-ylmethyl)-azetidin-2(s)-carboxamide
反応式
FC(F)(F)C(O)=O.[NH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([CH2:19][NH:20][C:21]([C@@H:23]3[CH2:26][CH2:25][N:24]3C(OC(C)(C)C)=O)=[O:22])=[CH:16][CH:17]=2)[CH:12]=[CH:11][N:10]=1>ClCCl>[NH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([CH2:19][NH:20][C:21]([C@@H:23]3[CH2:26][CH2:25][NH:24]3)=[O:22])=[CH:16][CH:17]=2)[CH:12]=[CH:11][N:10]=1参加物
4
実験手順
10 mL Trifluoroacetic acid was added to a solution of 2,4 g of N-(1-amino-isoquinolin-6-ylmethyl)-1-tert.butoxycarbonyl-azetidin-2(S)-carboxamide in 5.0 mL dichloromethane. The solvent was removed i.vac to give 2.1 g of the title compound as trifluoroacetate salt. MS: 371.
後処理
- customThe solvent was removed i.vac
出典と根拠
- ORDレコード
- ord-6ce8b70db32e4c548ebe19170d4f1325
- 出典データセット
- uspto-grants-2004_09
- 特許番号
- US06797710B2
反応ノート
読み込み中…