Quinuclidine → 1-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

HRID 1008756ノート

反応式

HRID 1008756 の反応式
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:9][CH2:10][CH2:11][CH2:12][N:13]=[C:14]=[S:15]>C(#N)C>[Br-:9].[N:13]([CH2:12][CH2:11][CH2:10][N+:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2)=[C:14]=[S:15]

参加物

4

反応物 2

HCID 7527QuinuclidineHCID 1377143-Bromopropyl isothiocyanate

生成物 1

HCID 231542151-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
50 °C

実験手順

Quinuclidine (33 mg) was added to a solution of 55 mg of 3-bromopropyl isothiocyanate in 1 mL of acetonitrile, and heated at 50° C. for 19 hours. The reaction solution was concentrated and then a residue was washed three times with 1 mL of ether, to yield the title compound.

後処理

  1. concentrationThe reaction solution was concentrated
  2. washa residue was washed three times with 1 mL of ether

出典と根拠

ORDレコード
ord-66e2c863a0c248eaadb9ccbc1142e6fc
出典データセット
uspto-grants-2011_07
特許番号
US07973030B2

反応ノート

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