反応式
[Mg].[CH2:2](Br)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].O=[C:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([CH3:25])[C:20]=2[O:26][CH3:27])[CH2:14][CH2:13]1.Cl.C1C[O:32]CC1>>[OH:32][C:5]([N:18]([CH:15]1[CH2:16][CH2:17][CH2:12][CH2:13][CH2:14]1)[C:19]1[CH:24]=[CH:23][N:22]=[C:21]([CH3:25])[C:20]=1[O:26][CH3:27])([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:4][CH2:3][CH3:2]参加物
6
実験手順
The Grignard solution is prepared from 0.73 g of magnesium and 6.0 g of octyl bromide in 50 ml of absolute THF. 2.8 g of 4-(4-oxocyclohexylamino)-3-methoxy-2-methylpyridine in 20 ml of THF are added dropwise to the solution. After 2 hours the mixture is acidified with 2N HCl. The THF is then distilled off in vacuo at room temperature and the product is extracted from the solution which is rendered alkaline with methylene chloride. Further working up takes place as in the previous working procedure.
後処理
- distillationThe THF is then distilled off in vacuo at room temperature
- extractionthe product is extracted from the solution which
出典と根拠
- ORDレコード
- ord-8babbf86aa35457596df795b424dbf27
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723450
関連ノート
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