Acetic Anhydride → Acetic acid 2-(1-methyl-1H-indol-7-yloxy)-ethyl ester

HRID 1009015

反応式

HRID 1009015 の反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[O:11][CH2:12][CH2:13][OH:14])[CH:4]=[CH:3]1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>N1C=CC=CC=1>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[O:11][CH2:12][CH2:13][O:14][C:15](=[O:17])[CH3:16])[CH:4]=[CH:3]1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 673047412-(1-Methyl-1H-indol-7-yloxy)-ethanol

生成物 1

HCID 67304991Acetic acid 2-(1-methyl-1H-indol-7-yloxy)-ethyl ester

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 2-(1-methyl-1H-indol-7-yloxy)-ethanol (0.78 g, 4 mmol) in pyridine (10 mL) was treated with acetic anhydride (5 mL). The reaction mixture was stirred at rt for 4 h and concentrated. The residue was quenched with ice/water and extracted with ethyl acetate. The organics were washed with 2N sulfuric acid, sat. sodium bicarbonate and brine, dried and concentrated. The residue was chromatographed on silica gel using heptanelethyl acetate as eluent to produce the desired compound (0.90 g) as an off-white solid. MS (ISP): m/e 234.1 (M+H)+

後処理

  1. concentrationconcentrated
  2. customThe residue was quenched with ice/water
  3. extractionextracted with ethyl acetate
  4. washThe organics were washed with 2N sulfuric acid, sat. sodium bicarbonate and brine
  5. customdried
  6. concentrationconcentrated
  7. customThe residue was chromatographed on silica gel using heptanelethyl acetate as eluent

出典と根拠

ORDレコード
ord-6df211154aa948ef91eb957b4b6645ce
出典データセット
uspto-grants-2011_07
特許番号
US07973051B2

関連ノート

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