Tert-butyl (5-ethynyl-4-methylthiazol-2-yl)carbamate → HCID 86630952、化合物

HRID 1009034ノート

反応式

HRID 1009034 の反応式
[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[S:9][C:10]([C:14]#[CH:15])=[C:11]([CH3:13])[N:12]=1)([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[S:9][C:10]([CH2:14][CH3:15])=[C:11]([CH3:13])[N:12]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 86630951Tert-butyl (5-ethynyl-4-methylthiazol-2-yl)carbamate

生成物 1

HCID 86630952HCID 86630952、化合物収率 92.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

The above prepared (5-ethynyl-4-methyl-thiazol-2-yl)-carbamic acid tert-butyl ester (0.420 g, 1.76 mmol) was dissolved in 12 mL of ethyl acetate and hydrogenated over 0.200 g of Pd on charcoal (10%) at atmospheric pressure and ambient temperature over night. Filtration over a pad of Celite and evaporation off all solvents yielded 0.396 g of the title product as light brown viscous oil, sufficiently pure for the next step.

後処理

  1. filtrationFiltration
  2. customover a pad of Celite and evaporation off all solvents

出典と根拠

ORDレコード
ord-81f38227d37f4ede8ea8309cfe12dee0
出典データセット
uspto-grants-2011_07
特許番号
US07973051B2

反応ノート

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