Hydrazine hydrate (1:1) → methyl 5-(aminomethyl)-1-methyl-1H-pyrrole-2-carboxylate
反応式
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][C:13]1[N:17]([CH3:18])[C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:14]=1.O.NN>CO>[NH2:3][CH2:12][C:13]1[N:17]([CH3:18])[C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:14]=1参加物
4
実験手順
650 mg of methyl 5-[(1,3-dioxo-1,3-dihydro-2H-isoindole-2-yl)methyl]-1-methyl-1H-pyrrole-2-carboxylate was dissolved in 20.0 mL of methanol, and 109 mg of hydrazine monohydrate was added thereto, followed by stirring at room temperature overnight. The reaction liquid was concentrated under reduced pressure, to the obtained residue was added chloroform, and the insolubles were filtered off. Then, the filtrate was concentrated under reduced pressure to obtain 294 mg of methyl 5-(aminomethyl)-1-methyl-1H-pyrrole-2-carboxylate.
後処理
- customThe reaction liquid
- concentrationwas concentrated under reduced pressure, to the obtained residue
- additionwas added chloroform
- filtrationthe insolubles were filtered off
- concentrationThen, the filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-963f5cd87b2d468b82f9b1459c63347e
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07973078B2
反応ノート
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