Ethanol → 6-Iodoindoline

HRID 1009609

反応式

HRID 1009609 の反応式
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([I:13])[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+].CCO>O>[I:13][C:10]1[CH:11]=[C:12]2[C:7]([CH2:6][CH2:5][NH:4]2)=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 116663961-Acetyl-6-iodoindoline

生成物 1

HCID 116156966-Iodoindoline収率 64%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1-Acetyl-6-iodoindoline (1.06 g, 3.7 mmol), NaOH (1.16 g, 29 mmol), EtOH (8 mL), and H2O (6 mL) are heated at 90° C. overnight. The reaction mixture is then partitioned between H2O and EtOAc. The organic layer is extracted into aqueous HCl. The aqueous layer is in turn basified with NaOH, and is extracted with EtOAc. The organic layer is dried and concentrated. Hexane trituration yields 6-iodoindoline (577 mg, 64%) as a brown solid.

後処理

  1. customThe reaction mixture is then partitioned between H2O and EtOAc
  2. extractionThe organic layer is extracted into aqueous HCl
  3. extractionis extracted with EtOAc
  4. customThe organic layer is dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-39c37c3b0c3d45a8b01105da888629fe
出典データセット
uspto-grants-2011_07
特許番号
US07973069B2

関連ノート

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