2-Methoxy-4-nitrophenol acetate → HCID 22646533、化合物

HRID 1009803ノート

反応式

HRID 1009803 の反応式
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:6]=1[O:14][CH3:15])(=[O:3])[CH3:2]>CCOC(C)=O.[Pd]>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][C:6]=1[O:14][CH3:15])(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 499852-Methoxy-4-nitrophenol acetate

生成物 1

HCID 22646533HCID 22646533、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a stirred solution of the 2-methoxy-4-nitrophenyl acetate prepared in Part A (99.2 mg, 0.47 mmol) in EtOAc (4.5 mL) was added palladium on carbon (33.0 mg, 5% dry basis, Degussa type: 50% water content). The suspension was hydrogenated (1 atm, balloon) for 3 h, filtered through CELITE® and the filter cake was rinsed with MeOH (5×10 mL). Evaporation of the combined filtrates gave the desired aniline (84.8 mg, quant.) as a brown oil: MS (electrospray, + ions) m/z 182 (M+H).

後処理

  1. customfor 3 h
  2. filtrationfiltered through CELITE®
  3. washthe filter cake was rinsed with MeOH (5×10 mL)
  4. customEvaporation of the combined filtrates

出典と根拠

ORDレコード
ord-a9f28f08a5034bafafe25bda7546d844
出典データセット
uspto-grants-2011_07
特許番号
US07973159B2

反応ノート

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