ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Ethanol → 4-(4-Aminophenoxy)-2-butyrylaminopyridine

HRID 1010324
ノート
印刷プレビュー

反応式

HRID 1010324 の反応式
[C:1]([NH:6][C:7]1[CH:12]=[C:11]([O:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)[CH:10]=[CH:9][N:8]=1)(=[O:5])[CH2:2][CH2:3][CH3:4].[Cl-].[NH4+].C(O)C.CN(C)C=O>[Fe].O>[NH2:20][C:17]1[CH:16]=[CH:15][C:14]([O:13][C:11]2[CH:10]=[CH:9][N:8]=[C:7]([NH:6][C:1](=[O:5])[CH2:2][CH2:3][CH3:4])[CH:12]=2)=[CH:19][CH:18]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 702EthanolHCID 6228DimethylformamideHCID 25517Ammonium ChlorideHCID 229366772-Butyroylamino-4-(4-nitrophenoxy)pyridine

生成物 1

HCID 229364634-(4-Aminophenoxy)-2-butyrylaminopyridine

試薬・触媒・溶媒 2

HCID 23925Iron触媒
HCID 962
Water
溶媒

反応条件

温度
100 °C

実験手順

A mixture of 0.6 g of 2-butyrylamino-4-(4-nitrophenoxy)pyridine, 1.2 g of iron powder, 2.8 g of ammonium chloride, 10 ml of ethanol, 10 ml of dimethylformamide and 5 ml of water was vigorously stirred at 100° C. for 10 minutes. The reaction was filtered with celite, the solvent was distilled off under reduced pressure, and then water was added to the filtrate and extraction was performed with ethyl acetate. The extract was dried over magnesium sulfate and the solvent distilled off under reduced pressure to obtain 0.6 g of the target substance as a light yellow solid.

後処理

  1. filtrationThe reaction was filtered with celite
  2. distillationthe solvent was distilled off under reduced pressure
  3. additionwater was added to the filtrate and extraction
  4. dry with materialThe extract was dried over magnesium sulfate
  5. distillationthe solvent distilled off under reduced pressure
  6. customto obtain 0.6 g of the target substance as a light yellow solid

出典と根拠

ORDレコード
ord-b2cc061429cd4e72b7703ea7790bed54
出典データセット
uspto-grants-2011_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07973160B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート