Hydrochloric Acid → HCID 22936444、化合物

HRID 1010364ノート

反応式

HRID 1010364 の反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:26]=[CH:25][C:7]([O:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([C:19]([O:21]C)=[O:20])[CH:17]=3)[N:12]=[CH:11][CH:10]=2)=[CH:6][C:5]=1[N+:27]([O-:29])=[O:28].Cl>CO>[Cl:3][C:4]1[CH:26]=[CH:25][C:7]([O:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=3)[N:12]=[CH:11][CH:10]=2)=[CH:6][C:5]=1[N+:27]([O-:29])=[O:28]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22936400HCID 22936400、化合物

生成物 1

HCID 22936444HCID 22936444、化合物収率 93.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

After adding methanol (30 ml) and 2N aqueous sodium hydroxide (10 ml) to methyl 4-(4-chloro-3-nitrophenoxy)-7-methoxy-6-quinolinecarboxylate (1.00 g, 2.57 mmol), the mixture was stirred at 60° C. for 1 hour. The reaction solution was allowed to cool to room temperature, 2N hydrochloric acid was added for neutralization, the methanol was distilled off, and the precipitated light brown crystals were filtered out, thoroughly washed with water and dried at 70° C. to obtain the title compound (897 mg, 2.39 mmol, 93.1%).

後処理

  1. temperatureto cool to room temperature
  2. distillationthe methanol was distilled off
  3. filtrationthe precipitated light brown crystals were filtered out
  4. washthoroughly washed with water
  5. customdried at 70° C.

出典と根拠

ORDレコード
ord-65cce2af7e684dae82f2d5394b2b895d
出典データセット
uspto-grants-2011_07
特許番号
US07973160B2

反応ノート

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