10-(Phenylmethyl)-5,8-dioxa-10-azadispiro[2.0.4.3]undecane → 5,8-Dioxa-10-azadispiro[2.0.4.3]undecane
反応式
C([N:8]1[CH2:14][C:11]2([CH2:13][CH2:12]2)[C:10]2([O:18][CH2:17][CH2:16][O:15]2)[CH2:9]1)C1C=CC=CC=1>CCO.[Pd]>[CH2:13]1[C:11]2([CH2:14][NH:8][CH2:9][C:10]32[O:15][CH2:16][CH2:17][O:18]3)[CH2:12]1参加物
4
実験手順
10-benzyl-5,8-Dioxa-10-azadispiro[2.0.4.3]undecane (A) (1.0 g, similar prepared according to JMC 37, 3344) was mixed with Pd—C (10%, 600 mg) in EtOH (40 ml) and hydrogenated under H2 at 50 psi for 5 hour. The reaction was filtered through Celite and evaporated to give 5,8-Dioxa-10-azadispiro[2.0.4.3]undecane (B).
後処理
- filtrationThe reaction was filtered through Celite
- customevaporated
出典と根拠
- ORDレコード
- ord-2fc18880c14545e0bf97678e81301cd0
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07977346B2
反応ノート
読み込み中…