2-Bromoethanol → 10-(2-hydroxyethyl)-5,8-Dioxa-10-azadispiro[2.0.4.3]undecane
反応式
[CH2:1]1[C:3]2([CH2:11][NH:10][CH2:9][C:4]32[O:8][CH2:7][CH2:6][O:5]3)[CH2:2]1.Br[CH2:13][CH2:14][OH:15].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[OH:15][CH2:14][CH2:13][N:10]1[CH2:11][C:3]2([CH2:1][CH2:2]2)[C:4]2([O:5][CH2:6][CH2:7][O:8]2)[CH2:9]1参加物
5
実験手順
The compound (B) (100 mg) was mixed with 2-Bromoethanol (100 mg) and K2CO3 (120 mg) in Acetonitrile. The reaction was refluxed overnight and filtered, the filtrate was evaporated and purified on silica gel column to give the titled product. Mass: (M+1), 200
後処理
- temperatureThe reaction was refluxed overnight
- filtrationfiltered
- customthe filtrate was evaporated
- custompurified on silica gel column
出典と根拠
- ORDレコード
- ord-68da0bef6e6647ec8ad3506260f2ab14
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07977346B2
反応ノート
読み込み中…