Sodium borohydride → 5-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-ol

HRID 1010798ノート

反応式

HRID 1010798 の反応式
[OH:1][CH2:2][CH2:3][N:4]1[CH2:10][C:9](=[O:11])[C:6]2([CH2:8][CH2:7]2)[CH2:5]1.[BH4-].[Na+]>CO>[OH:1][CH2:2][CH2:3][N:4]1[CH2:10][CH:9]([OH:11])[C:6]2([CH2:7][CH2:8]2)[CH2:5]1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 167382835-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-one

生成物 1

HCID 167382855-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-one (100 mg) was dissolved into Methanol (8 ml) and stirred at RT. NaBH4 (100 mg) was added to the reaction and stirred at RT for 30 minutes. The reaction was evaporated and purified by column chromatography to give title compound. Mass: (M+1), 158

後処理

  1. stirringstirred at RT for 30 minutes
  2. customThe reaction was evaporated
  3. custompurified by column chromatography

出典と根拠

ORDレコード
ord-0effb4b5009a43d2a870d2f4eaaaca35
出典データセット
uspto-grants-2011_07
特許番号
US07977346B2

反応ノート

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