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Hydrochloric Acid → 2-(2-Fluoro-phenyl)-3H-thieno[2,3-d]pyrimidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-(2-Fluorobenzamido)thiophene-3-carboxamide | HCID 7164102 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 2-(2-Fluoro-phenyl)-3H-thieno[2,3-d]pyrimidin-4-one | HCID 21104303 | 68% |
反応手順
2-(2-Fluoro-benzoylamino)-thiophene-3-carboxylic acid amide (8.56 g, 32.4 mmole) was dissolved in a mixture of 20 ml 1 M sodium hydroxide and 60 ml ethanol. The mixture was brought to reflux for 4 hours. The reaction mixture was cooled and poured onto ice. The solution was acidified with dilute hydrochloric acid and the product was isolated by filtration. Upon vacuum drying 5.42 g of product was obtained (Yield: 68%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07977342B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-49d4cdb32c5b44ea8d7d4212bb8dc3d0 |
| 出典メモ | uspto-grants-2011_07 |