反应详情

2-(2-Fluoro-benzoylamino)-thiophene-3-carboxylic acid amide (8.56 g, 32.4 mmole) was dissolved in a mixture of 20 ml 1 M sodium hydroxide and 60 ml ethanol. The mixture was brought to reflux for 4 hours. The reaction mixture was cooled and poured onto ice. The solution was acidified with dilute hydrochloric acid and the product was isolated by filtration. Upon vacuum drying 5.42 g of product was obtained (Yield: 68%).

1. temperatureto reflux for 4 hours
2. temperatureThe reaction mixture was cooled
3. additionpoured onto ice
4. customthe product was isolated by filtration
5. dry with materialUpon vacuum drying 5.42 g of product
6. customwas obtained (Yield: 68%)