Trifluoroacetic acid → 2-[(2,2-Dimethylpentyl)oxy]-8-methoxy-9h-purin-6-amine trifluoroacetic acid salt

HRID 1010949ノート

反応式

HRID 1010949 の反応式
[CH3:1][C:2]([CH3:26])([CH2:23][CH2:24][CH3:25])[CH2:3][O:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([O:20][CH3:21])[N:11]2C2CCCCO2)=[C:7]([NH2:22])[N:6]=1.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28]>CO>[F:30][C:29]([F:32])([F:31])[C:27]([OH:33])=[O:28].[CH3:1][C:2]([CH3:26])([CH2:23][CH2:24][CH3:25])[CH2:3][O:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([O:20][CH3:21])[NH:11]2)=[C:7]([NH2:22])[N:6]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 576996322-[(2,2-Dimethylpentyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-Purin-6-amine

生成物 1

HCID 1784440732-[(2,2-Dimethylpentyl)oxy]-8-methoxy-9h-purin-6-amine trifluoroacetic acid salt

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-[(2,2-dimethylpentyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (323 mg) in dry MeOH (3.23 mL) was added TFA (0.323 mL) and the reaction was stirred at room temperature for 48 h. The reaction was concentrated in vacuo to give a yellow residue. The residue was triturated with Et2O and was filtered to give the title compound as an off-white solid (252 mg).

後処理

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give a yellow residue
  3. customThe residue was triturated with Et2O
  4. filtrationwas filtered

出典と根拠

ORDレコード
ord-0cef73a619304326896e486b2f08b258
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

反応ノート

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