Trifluoroacetic acid → HCID 178493996、化合物

HRID 1010959ノート

反応式

HRID 1010959 の反応式
[CH3:1][CH:2]([CH3:24])[CH2:3][CH2:4][O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:21][CH3:22])[N:12]2C2CCCCO2)=[C:8]([NH2:23])[N:7]=1.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH3:1][CH:2]([CH3:24])[CH2:3][CH2:4][O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:21][CH3:22])[NH:12]2)=[C:8]([NH2:23])[N:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 57699783HCID 57699783、化合物

生成物 1

HCID 178493996HCID 178493996、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-[(3-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (210 mg) in dry MeOH (2.1 mL) was added TFA (0.21 ml) and the mixture was stirred at room temperature for 24 h. The reaction was concentrated in vacuo to give a yellow residue which was triturated with Et2O (15 mL) and filtered under reduced pressure to give the title compound as an off-white solid (143 mg).

後処理

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give a yellow residue which
  3. customwas triturated with Et2O (15 mL)
  4. filtrationfiltered under reduced pressure

出典と根拠

ORDレコード
ord-bb1f24f3bd604e7887cfaed5fefa6890
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

反応ノート

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