Trifluoroacetic acid → HCID 178447009、化合物

HRID 1010970ノート

反応式

HRID 1010970 の反応式
[CH3:1][CH:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[N:13]2C2CCCCO2)=[C:9]([NH2:24])[N:8]=1)[CH2:3][CH2:4][CH3:5].[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH3:1][CH:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[NH:13]2)=[C:9]([NH2:24])[N:8]=1)[CH2:3][CH2:4][CH3:5]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 576997022-[(1-Methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-Purin-6-amine

生成物 1

HCID 178447009HCID 178447009、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-[(1-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (313 mg) in dry MeOH (3.13 mL) was added TFA (0.313 mL) and the mixture was stirred at room temperature for 48 h. The reaction mixture was concentrated in vacuo to give a yellow residue which was triturated with Et2O and filtered to give the title compound as an off-white solid (218 mg).

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto give a yellow residue which
  3. customwas triturated with Et2O
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-5c8bbd0f9df4412bb9bcfeb4618ca128
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

反応ノート

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