Trifluoroacetic acid → HCID 178493994、化合物

HRID 1010979ノート

反応式

HRID 1010979 の反応式
[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[N:15]=[C:14]3[C:10]([N:11]=[C:12]([O:22][CH3:23])[N:13]3C3CCCCO3)=[C:9]([NH2:24])[N:8]=2)[CH2:3][CH2:2]1.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26].CCOC(C)=O>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH:1]1([CH2:4][CH2:5][O:6][C:7]2[N:15]=[C:14]3[C:10]([N:11]=[C:12]([O:22][CH3:23])[NH:13]3)=[C:9]([NH2:24])[N:8]=2)[CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 576996292-[(2-Cyclopropylethyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

生成物 1

HCID 178493994HCID 178493994、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-[(2-Cyclopropylethyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (845 mg) was dissolved in MeOH (10 mL) and TFA (1 mL) was added. The reaction was stirred over a weekend and was evaporated to dryness under reduced pressure to give a brown solid. EtOAc was added and the solid was filtered off and washed with more EtOAc (15 mL EtOAc used in total). The solid was then washed with Et2O (5 mL) and air-dried under suction to give the title compound as an off-white solid (937 mg).

後処理

  1. customwas evaporated to dryness under reduced pressure
  2. customto give a brown solid
  3. filtrationthe solid was filtered off
  4. washwashed with more EtOAc (15 mL EtOAc used in total)
  5. washThe solid was then washed with Et2O (5 mL)
  6. customair-dried under suction

出典と根拠

ORDレコード
ord-2c46f7b4dbae404d8a52d6c3d32fde52
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

反応ノート

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