Trifluoroacetic acid → HCID 178493992、化合物

HRID 1011032ノート

反応式

HRID 1011032 の反応式
[CH3:1][O:2][C:3]1[N:4](C2CCCCO2)[C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][O:16]1)[N:6]=2.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>CO>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH3:1][O:2][C:3]1[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][O:16]1)[N:6]=2

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 576998158-(Methoxy)-2-[(tetrahydro-2-furanylmethyl)oxy]-9-(tetrahydro-2H-Pyran-2-yl)-9H-purin-6-amine

生成物 1

HCID 178493992HCID 178493992、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

8-(Methoxy)-2-[(tetrahydro-2-furanyl methyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (1.1614 g) was dissolved in methanol (20 mL) and treated with neat trifluoroacetic acid (2 mL). The reaction mixture was stirred for 24 hours to give a white suspension. The reaction mixture was then evaporated to dryness under reduced pressure. The resultant white solid was suspended using ethyl acetate (10 mL) and then isolated by filtration, washing with ethyl acetate (2 mL). The solid was air-dried under suction and then dried further under vacuo at 50° C. This gave the title compound as a white solid (1.0602 g).

後処理

  1. customto give a white suspension
  2. customThe reaction mixture was then evaporated to dryness under reduced pressure
  3. customisolated by filtration
  4. washwashing with ethyl acetate (2 mL)
  5. customThe solid was air-dried under suction
  6. customdried further under vacuo at 50° C

出典と根拠

ORDレコード
ord-70d691defeeb4f9895a0a8af6cace0e2
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

反応ノート

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