Phthalic Anhydride → 2-{[(Tetrahydro-3-furanylmethyl)oxy]carbonyl}benzoic acid

HRID 1011054ノート

反応式

HRID 1011054 の反応式
[C:1]1(=[O:11])[O:6][C:4](=[O:5])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[O:12]1[CH2:16][CH2:15][CH:14]([CH2:17][OH:18])[CH2:13]1>O>[O:12]1[CH2:16][CH2:15][CH:14]([CH2:17][O:18][C:4]([C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=2[C:1]([OH:6])=[O:11])=[O:5])[CH2:13]1

参加物

4

反応物 2

HCID 6811Phthalic AnhydrideHCID 139980Tetrahydro-3-furanmethanol

生成物 1

HCID 576996462-{[(Tetrahydro-3-furanylmethyl)oxy]carbonyl}benzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
130 °C

実験手順

A mixture of phthalic anhydride (7.41 gm) and tetrahydro-3-furanmethanol were heated with stirring at 130° C. under nitrogen. After 1.5 h, the clear liquid was allowed to cool, treated with water and extracted with EtOAc (×3). The combined organics were dried by passing through a hydrophobic frit and evaporated to a clear oil which crystallised on trituration with light petrol. The solid was filtered, washed and dried, yield 11.93 gm.

後処理

  1. temperaturewere heated
  2. temperatureto cool
  3. extractionextracted with EtOAc (×3)
  4. customThe combined organics were dried
  5. customevaporated to a clear oil which
  6. customcrystallised on trituration with light petrol
  7. filtrationThe solid was filtered
  8. washwashed
  9. customdried

出典と根拠

ORDレコード
ord-7e6681590e1f4d2c9a373d7122c14399
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

反応ノート

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