Hydrochloric Acid → 6-Amino-2-(butyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-7,9-dihydro-8H-purin-8-one

HRID 1011206ノート

反応式

HRID 1011206 の反応式
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]2[CH2:22][CH2:21][O:20][CH2:19]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl.[OH-].[Na+]>CO.O1CCOCC1>[NH2:25][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH2:17][CH:18]1[CH2:22][CH2:21][O:20][CH2:19]1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 576996812-(Butyloxy)-8-(methyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-9H-purin-6-amine

生成物 1

HCID 576995966-Amino-2-(butyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-7,9-dihydro-8H-purin-8-one収率 70%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 2-(butyloxy)-8-(methyloxy)-9-[3-(tetrahydro-3-furanyl)propyl]-9H-purin-6-amine (110 mg, 0.315 mmol) in methanol (9 ml) at room temperature was added 4M HCl in dioxane (1.89 ml). The pale yellow solution was stirred at room temperature for 18 hrs and then neutralised with 2M sodium hydroxide solution and evaporated to give a white solid. Trituration with water and filtration afforded the title compound as a cream solid (74 mg).

後処理

  1. customevaporated
  2. customto give a white solid
  3. filtrationTrituration with water and filtration

出典と根拠

ORDレコード
ord-20cebc6e456c41ad8c16fb90837aa8a4
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

反応ノート

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