Benzyl Bromide → HCID 23159744、化合物

HRID 1011425ノート

反応式

HRID 1011425 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:6]=[N:7]2.C([O-])([O-])=O.[Na+].[Na+].[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CN(C=O)C.O>[CH2:23]([O:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[C:5]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:6]=[N:7]2)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

6

反応物 3

HCID 7498Benzyl BromideHCID 10340Sodium CarbonateHCID 135618214ethyl 5-hydroxyquinoline-3-carboxylate

生成物 1

HCID 23159744HCID 23159744、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A solution of ethyl 5-hydroxyquinoline-3-carboxylate (2.17 g, 10 mmol) prepared in stage D of example 2, Na2CO3 (2.12 g, 20 mmol) and benzylbromide (1.71 g, 10 mmol) in DMF (20 mL) was stirred for 12 hours at room temperature. The reaction mixture was diluted with water (50 mL) and then extracted with AcOEt (3×25 mL). The combined organic layers were washed water, and dried over Magnesium sulfate and evaporated under reduced pressure. The obtained residue was chromatographed over silica-gel.

後処理

  1. extractionextracted with AcOEt (3×25 mL)
  2. washThe combined organic layers were washed water
  3. dry with materialdried over Magnesium sulfate
  4. customevaporated under reduced pressure
  5. customThe obtained residue was chromatographed over silica-gel

出典と根拠

ORDレコード
ord-b6cf759d46af4eefb72a608bfe7a8487
出典データセット
uspto-grants-2011_07
特許番号
US07977354B2

反応ノート

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