2-Aminocarbonylamino-5-(4-vinylphenyl)pyrrole-3-carboxamide → 2-Aminocarbonylamino-5-(4-ethylphenyl)pyrrole-3-carboxamide

HRID 1011582ノート

反応式

HRID 1011582 の反応式
[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:18]=[CH:17][C:16]([CH:19]=[CH2:20])=[CH:15][CH:14]=2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]>[Pd].CO>[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][CH:14]=2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]

参加物

4

反応物 1

HCID 250029182-Aminocarbonylamino-5-(4-vinylphenyl)pyrrole-3-carboxamide

生成物 1

HCID 592858602-Aminocarbonylamino-5-(4-ethylphenyl)pyrrole-3-carboxamide収率 62.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10% Palladium on activated carbon (6 mg) was added to a solution of 2-aminocarbonylamino-5-(4-vinylphenyl)pyrrole-3-carboxamide (Compound No. 9-1, 16 mg, 0.059 mmol) in methanol (2 mL) and the mixture was stirred at room temperature for 4.5 hours under hydrogen gas atmosphere. After the reaction solution was filtered, the filterate was concentrated in vacuo. The obtained solid was washed with diethyl ether (2 mL) and dried under reduced pressure to give the target compound (10 mg) as a colorless solid (Yield 62%).

後処理

  1. filtrationAfter the reaction solution was filtered
  2. concentrationthe filterate was concentrated in vacuo
  3. washThe obtained solid was washed with diethyl ether (2 mL)
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-ec598e5e53524e5fa5571f59ffa87c96
出典データセット
uspto-grants-2011_07
特許番号
US07977371B2

反応ノート

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