trans-2-(4-Chlorophenyl)vinylboronic acid → HCID 57554998、化合物

HRID 1011918

反応式

HRID 1011918 の反応式
Br[C:2]1[CH:3]=[C:4]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([N:16]3[CH2:20][CH2:19][CH:18]([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[CH2:17]3)=[O:15])[C:10]([CH3:26])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[Cl:27][C:28]1[CH:33]=[CH:32][C:31](/[CH:34]=[CH:35]/B(O)O)=[CH:30][CH:29]=1>>[Cl:27][C:28]1[CH:33]=[CH:32][C:31](/[CH:34]=[CH:35]/[C:2]2[CH:3]=[C:4]([N:8]3[C:12]([CH3:13])=[C:11]([C:14]([N:16]4[CH2:20][CH2:19][CH:18]([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[CH2:17]4)=[O:15])[C:10]([CH3:26])=[N:9]3)[CH:5]=[CH:6][CH:7]=2)=[CH:30][CH:29]=1

参加物

3

反応物 2

HCID 642694trans-2-(4-Chlorophenyl)vinylboronic acidHCID 67313795[1-(3-Bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone

生成物 1

HCID 57554998HCID 57554998、化合物収率 67%

実験手順

In analogy to the procedure described in Example 14C], [1-(3-bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone (Example 28A]) and trans-2-(4-chlorophenyl)vinylboronic acid gave the title compound in 67% yield as light brown foam. MS: 477.3 (MH+, 1 Cl).

出典と根拠

ORDレコード
ord-04b8153fdbc94b5e99b877891c9a8e96
出典データセット
uspto-grants-2011_07
特許番号
US07977358B2

関連ノート

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