(3,4-Dinitrophenyl)(morpholino)methanone → (3,4-diaMinophenyl)(Morpholino)Methanone

HRID 1012090ノート

反応式

HRID 1012090 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:14])[CH:7]=[CH:8][C:9]=1[N+:10]([O-])=O)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:13]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:14])[CH:7]=[CH:8][C:9]=1[NH2:10]

参加物

4

反応物 1

HCID 13043973(3,4-Dinitrophenyl)(morpholino)methanone

生成物 1

HCID 22411123(3,4-diaMinophenyl)(Morpholino)Methanone収率 114.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of (3,4-dinitro-phenyl)-morpholin-4-yl-methanone (1.0 g) and 10% Pd/C (150 mg) in MeOH (30 ml) was shaken under a hydrogen atmosphere at ambient temperature for 10 hours, then filtered through a plug of Celite and reduced in vacuo to give (3,4-diamino-phenyl)-morpholin-4-yl-methanone (900 mg). (1H NMR (300 MHz, DMSO-d6) δ 6.6 (s, 1H), 6.5 (s, 2H), 4.8 (s, 1.5H), 4.6 (s, 1.5H), 4.1 (s, 1H), 3.6 (m, 4H), 3.4 (m, 4H)).

後処理

  1. filtrationfiltered through a plug of Celite

出典と根拠

ORDレコード
ord-3d27d4158a2a464a9096147a81fb0415
出典データセット
uspto-grants-2011_07
特許番号
US07977477B2

反応ノート

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