4-(3,4-Dinitrobenzyl)morpholine → 4-(Morpholinomethyl)benzene-1,2-diamine

HRID 1012092ノート

反応式

HRID 1012092 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][C:16]=1[N+:17]([O-])=O)[CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)([O-])=O>CO.[Pd]>[N:8]1([CH2:7][C:6]2[CH:5]=[C:4]([NH2:1])[C:16]([NH2:17])=[CH:15][CH:14]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

参加物

4

反応物 1

HCID 251933104-(3,4-Dinitrobenzyl)morpholine

生成物 1

HCID 251933094-(Morpholinomethyl)benzene-1,2-diamine収率 113.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 4-(3,4-dinitro-benzyl)-morpholine (550 mg) and 10% Pd/C (75 mg) in MeOH (10 ml) was shaken under a hydrogen atmosphere at ambient temperature for 4 hours, then filtered through a plug of Celite and reduced in vacuo to give 4-morpholin-4-ylmethyl-benzene-1,2-diamine (483 mg) as the major component of a mixture.

後処理

  1. filtrationfiltered through a plug of Celite

出典と根拠

ORDレコード
ord-5b99c5fb516745b3a2dcef540ddef763
出典データセット
uspto-grants-2011_07
特許番号
US07977477B2

反応ノート

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