Sodium Hydroxide → HCID 67314829、化合物
反応式
Cl.[C:2]([O:5][CH2:6][CH2:7][N:8]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][NH2:28])=[CH:23][CH:22]=1)[CH2:9][CH2:10][CH2:11][CH2:12][N:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16])(=[O:4])[CH3:3].[OH-].[Na+]>O>[C:2]([O:5][CH2:6][CH2:7][N:8]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][NH2:28])=[CH:23][CH:22]=1)[CH2:9][CH2:10][CH2:11][CH2:12][N:13]([CH2:14][CH2:15][CH3:16])[CH2:17][CH2:18][CH3:19])(=[O:4])[CH3:3]参加物
4
実験手順
5.8 g of the obtained [(4-aminomethylbenzyl)-(4-dipropylaminobutyl)amino]ethyl acetate hydrochloride (14a) was dissolved in 30 ml of water. After the addition of a 1N sodium hydroxide aqueous solution (pH=1), the mixture was extracted twice with 100 ml of chloroform. The chloroform layer was washed with 30 ml of water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure, thereby obtaining 4.45 g of [(4-aminomethylbenzyl)-(4-dipropylaminobutyl)amino]ethyl acetate (14) as a colorless oily substance (yield: 99%, GC: 99.3%).