Di-tert-butyl (2S)-2-[(3-{[5-oxido-4-(phenylsulphonyl)-1,2,5-oxadiazol-3-yl]-oxy}-propionyl)-amino]-pentanedioate → (2S)-2-[(3-{[5-Oxido-4-(phenylsulphonyl)-1,2,5-oxadiazol-3-yl]-oxy}-propionyl)-amino]-pentanedioic Acid

HRID 1013435ノート

反応式

HRID 1013435 の反応式
[O-:1][N+:2]1[O:6][N:5]=[C:4]([O:7][CH2:8][CH2:9][C:10]([NH:12][C@@H:13]([CH2:21][CH2:22][C:23]([O:25]C(C)(C)C)=[O:24])[C:14]([O:16]C(C)(C)C)=[O:15])=[O:11])[C:3]=1[S:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:32])=[O:31]>ClCCl.C(O)(C(F)(F)F)=O>[O-:1][N+:2]1[O:6][N:5]=[C:4]([O:7][CH2:8][CH2:9][C:10]([NH:12][C@@H:13]([CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:14]([OH:16])=[O:15])=[O:11])[C:3]=1[S:30]([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)(=[O:31])=[O:32]

参加物

4

反応物 1

HCID 67317279Di-tert-butyl (2S)-2-[(3-{[5-oxido-4-(phenylsulphonyl)-1,2,5-oxadiazol-3-yl]-oxy}-propionyl)-amino]-pentanedioate

生成物 1

HCID 57626191(2S)-2-[(3-{[5-Oxido-4-(phenylsulphonyl)-1,2,5-oxadiazol-3-yl]-oxy}-propionyl)-amino]-pentanedioic Acid

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of the compound obtained in Step A (3 g-5.5 mmol) in 100 ml of dichloromethane and 15 ml of TFA is stirred for 6 hours under argon. The solvents are distilled off in vacuo. The residue is triturated in diisopropyl ether, filtered off with suction and then dried in vacuo to yield the expected product in the form of white crystals.

後処理

  1. distillationThe solvents are distilled off in vacuo
  2. customThe residue is triturated in diisopropyl ether
  3. filtrationfiltered off with suction
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-664d00725b2145178573f976119139a1
出典データセット
uspto-grants-2011_07
特許番号
US07981920B2

反応ノート

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