1-Chloro-4-phenylphthalazine → HCID 59427352、化合物

反応式

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:4][N:3]=1.[CH3:18][O:19][C:20]1[CH:29]=[C:28]2[C:23]([C:24]([CH2:30][C:31]3[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][CH:32]=3)=[CH:25][CH:26]=[N:27]2)=[CH:22][CH:21]=1>CC(O)(C)C.C(Cl)Cl>[CH3:18][O:19][C:20]1[CH:29]=[C:28]2[C:23]([C:24]([CH2:30][C:31]3[CH:32]=[CH:33][C:34]([NH:37][C:2]4[C:11]5[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=5)[C:5]([C:12]5[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=5)=[N:4][N:3]=4)=[CH:35][CH:36]=3)=[CH:25][CH:26]=[N:27]2)=[CH:22][CH:21]=1

参加物

反応条件

温度: 105 °C

実験手順

A mixture of 1-chloro-4-phenylphthalazine (0.082 g, 0.34 mmol) and 4-((7-methoxyquinolin-4-yl)methyl)benzenamine (0.090 g, 0.34 mmol) in tBuOH (2.5 mL) was heated to 105° C. in a resealable tube. After 3 hrs, the mixture was cooled to RT, diluted with CH2Cl2 and washed with saturated NaHCO3 and brine. The organic fraction was dried with Na2SO4, concentrated in vacuo, and purified by silica gel chromatography using 50-100% Hexanes:EtOAc to afford N-(4-((7-methoxyquinolin-4-yl)methyl)phenyl)-4-phenylphthalazin-1-amine as a light yellow solid. [email protected] min