1H-indazol-7-amine → 4,5,6,7-tetrahydro-1H-indazol-7-amine

関与物質

役割	名称	HCID	仕込み量
反応物	1H-indazol-7-amine	HCID 88901	—
触媒	Rhodium	HCID 23948	—
溶媒	Ethanol	HCID 702	—
生成物	4,5,6,7-tetrahydro-1H-indazol-7-amine	HCID 21941962	28%

反応手順

Combine 1H-indazol-7-ylamine (5.0 g, 37.6 mmol) and 5% Rh/C (2.45 g) in ethanol (120 mL) and heat at 120° C. for 48 hours under ˜1000 psi H2. Cool the reaction and filter through hyflo. Remove the solvent in vacuo and purify the crude product with 5% 2 M NH3 in MeOH in CH2Cl2 to afford 1.43 g (28%) of the titled product. MS (m/z): 138 (M+1).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07981918B2
出典データセット	uspto-grants-2011_07
ORD ID	ord-0c2ef847358947b4850acc0bc880c4ca
出典メモ	uspto-grants-2011_07