反应详情

Combine 1H-indazol-7-ylamine (5.0 g, 37.6 mmol) and 5% Rh/C (2.45 g) in ethanol (120 mL) and heat at 120° C. for 48 hours under ˜1000 psi H2. Cool the reaction and filter through hyflo. Remove the solvent in vacuo and purify the crude product with 5% 2 M NH3 in MeOH in CH2Cl2 to afford 1.43 g (28%) of the titled product. MS (m/z): 138 (M+1).

1. temperatureCool
2. customthe reaction
3. filtrationfilter through hyflo
4. customRemove the solvent in vacuo
5. custompurify the crude product with 5% 2 M NH3 in MeOH in CH2Cl2