Sodium Azide → (R)-1-azido-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol

反応式

Cl[CH2:2][C@H:3]([OH:20])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:12][CH:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16])[CH:6]=1.[N-:21]=[N+:22]=[N-:23].[Na+]>>[N:21]([CH2:2][C@H:3]([OH:20])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:12][CH:13]([CH2:17][CH2:18][CH3:19])[CH2:14][CH2:15][CH3:16])[CH:6]=1)=[N+:22]=[N-:23]

参加物

反応物 2

HCID 33557Sodium Azide

HCID 67317608(R)-1-chloro-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol

生成物 1

HCID 86637618(R)-1-azido-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol

実験手順

Treatment of (R)-1-chloro-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol with sodium azide following the method used in Example 66 gave (R)-1-azido-3-(3-(2-propylpentyloxy)phenyl)propan-2-ol which was used without further purification.

出典と根拠

ORDレコード: ord-bbca3835fa354cfbba3530c8e72be000
出典データセット: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07982071B2

反応ノート

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