Trifluoroacetic acid → 5H-Benzo(6,7)cyclohepta(1,2-d)pyrimidin-2-amine, 4-((3R)-3-amino-1-pyrrolidinyl)-6,7-dihydro-
反応式
C(OC([NH:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[C:15]3[CH2:25][CH2:24][CH2:23][C:22]4[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=4[C:16]=3[N:17]=[C:18]([NH2:20])[N:19]=2)[CH2:10]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[C:15]3[CH2:25][CH2:24][CH2:23][C:22]4[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=4[C:16]=3[N:17]=[C:18]([NH2:20])[N:19]=2)[CH2:10]1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
A solution of the product from Example 4D (68 mg, 0.17 mmol) in CH2Cl2 (3 mL) was treated with trifluoroacetic acid (0.2 mL) and stirred for 16 hours. The mixture was diluted with CH2Cl2, washed H2O, dried, concentrated and chromatographed on silica gel eluting with eluting with NH4OH/MeOH/CH2Cl2 (0.8/8/92) to provide the title compound.