5,5'-Bi-2-benzofuran-1,1',3,3'-tetrone → 3,3',4,4'-Tetra(hydroxymethyl)-1,1'-biphenyl

HRID 1015454

反応式

HRID 1015454 の反応式
[CH:1]1[C:6]([C:7]2[CH:12]=[CH:11][C:10]3[C:13]([O:15][C:16](=O)[C:9]=3[CH:8]=2)=[O:14])=[CH:5][C:4]2[C:18]([O:20][C:21](=O)[C:3]=2[CH:2]=1)=[O:19].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCOCC1>[OH:15][CH2:16][C:9]1[CH:8]=[C:7]([C:6]2[CH:1]=[CH:2][C:3]([CH2:21][OH:20])=[C:4]([CH2:18][OH:19])[CH:5]=2)[CH:12]=[CH:11][C:10]=1[CH2:13][OH:14]

参加物

4

反応物 2

HCID 754945,5'-Bi-2-benzofuran-1,1',3,3'-tetroneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 597794533,3',4,4'-Tetra(hydroxymethyl)-1,1'-biphenyl

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Compound 4 is prepared in two steps from commercially available 3,3′,4,4′-biphenyltetracarboxylic dianhydride as shown in Scheme 4. Dianhydride is reduced with lithium aluminium hydride in dioxane to give 3,3′,4,4′-tetra(hydroxymethyl)-1,1′-biphenyl 3, which is in turn oxidised following a standard swern oxidation procedure to afford tetracarbaldehyde 4.

出典と根拠

ORDレコード
ord-b740ec811d494b5cbb35fc0c6bfd471a
出典データセット
uspto-grants-2011_07
特許番号
US07985353B2

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