Chlorotrimethylsilane → (2S)-1-[N-(2-phenylhexahydro-2,5-methanopentalen-3a(1H)-yl)glycyl]pyrrolidine-2-carbonitrile
反応式
O=C1CCCN1[C:7]12[CH2:26][CH:11]3[CH2:12][C:13]([NH:15][CH2:16][C:17]([N:19]4[CH2:23][CH2:22][CH2:21][C@H:20]4[C:24]#[N:25])=[O:18])([CH2:14]1)[CH:9]([CH2:10]3)[CH2:8]2.[Si](Cl)(C)(C)C>CO>[C:7]1([C:7]23[CH2:26][CH:11]4[CH2:12][C:13]([NH:15][CH2:16][C:17]([N:19]5[CH2:23][CH2:22][CH2:21][C@H:20]5[C:24]#[N:25])=[O:18])([CH2:14]2)[CH:9]([CH2:10]4)[CH2:8]3)[CH:26]=[CH:11][CH:10]=[CH:9][CH:8]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
To a stirred solution of the compound obtained from example 26 (35 mg, 0.1 mmol) in methanol (2 mL) cooled to 0° C. was added TMS-Cl (25 μL, 0.2 mmol). After 30 minutes, the volatiles were removed under reduced pressure and the residue was triturated several times with diethyl ether to obtain the hydrochloride salt of (2S)-1-[N-(2-phenylhexahydro-2,5-methanopentalen-3a(1H)-yl)glycyl]pyrrolidine-2-carbonitrile as an off-white solid (38 mg).