クロロトリメチルシラン

解説クロロトリメチルシラン，金属ケイ素と塩化メチルを銅触媒を用いて高温で反応させるRochowの直接法によって合成される．刺激臭のある無色の液体．融点－40 ℃，沸点57.9 ℃．0.854．1.389．水とはげしく反応し，塩化水素を副生してヘキサメチルジシロキサンを生成する．種々の求核試剤と反応し，合成化学的に有用なシリルエーテル，有機ケイ素化合物などの合成原料となる．腐食性および刺激性がある．

用途主たる用途は????????化剤として合成反応に使用される。また、シリコーンオイル、シリコーン系撥水剤等のメチル系シロキサンポリマーの重合鎖末端停止剤である。

用途ガスクロマトグラフ分析における試料の前処理剤(トリメチルシリル化剤)。有機合成:和光試薬時報Vol.64 No.2,p.26(1996)、Vol.61 No.3,p.22(1993)。

使用Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.

一般的な説明Trimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135° F, Flash point -18°F. Density 0.854g/cm3. The vapor and liquid may cause burns. Vapors are heavier than air.

純化方法Likely impurities are other chlorinated methylsilanes and tetrachlorosilane (b 57.6o), some of which can form azeotropes. To avoid the latter, very efficient fractional distillation is required. It has been fractionated through a 12 plate glass helices-packed column with only the heart-cut material being used. It has also been fractionated through a 90cm, 19mm diameter Stedman column (p 11). Purify it by redistilling from CaH2 before use. [Sauer et al. J Am Chem Soc 70, 4254 1948, Sauer & Hadsell J Am Chem Soc 70 4258 1948, Langer et al. J Org Chem 23 50 1958, Beilstein 4 IV 4007.] FLAMMABLE and CORROSIVE.