Sodium Hydroxide → 3-Methyl-cyclopent-3-enecarboxylic acid
反応式
C([O:3][C:4]([CH:6]1[CH2:10][CH:9]=[C:8]([CH3:11])[CH2:7]1)=[O:5])C.[OH-].[Na+]>CO>[CH3:11][C:8]1[CH2:7][CH:6]([C:4]([OH:5])=[O:3])[CH2:10][CH:9]=1参加物
4
実験手順
A solution of the 3-Methyl-cyclopent-3-enecarboxylic acid ethyl ester (255 mg, 1.65 mmol) in MeOH (4.0 mL) and 10% aq. NaOH (3.3 mL, 8.25 mmol) was heated at 50° C. for 16 h, reaction mixture was cooled to room temperature, solvent was evaporated, diluted with water. The aqueous solution was washed with ether, and acidified with aq. 1 N HCl, extracted with ether. The ethereal solution was washed with brine and dried. Evaporation of the solvent furnished the 3-Methyl-cyclopent-3-enecarboxylic acid (200 mg, 97% yield). 1H NMR (CDCl3, 400 MHz), 5.27 (brs, 1H), 3.26-3.17 (m, 1H), 2.7-2.55 (m, 4H), 1.74 (s; 3H).
後処理
- customreaction mixture
- customsolvent was evaporated
- additiondiluted with water
- washThe aqueous solution was washed with ether
- extractionextracted with ether
- washThe ethereal solution was washed with brine
- customdried
- customEvaporation of the solvent
出典と根拠
- ORDレコード
- ord-bc73a6d8800a435b871cd16af9b681e8
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07985769B2
反応ノート
読み込み中…