化工社化工社 化学情報印刷レポート · 研究参考用
4-Fluoro-2-(hydroxymethyl)phenol → (5-Fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluoro-2-(hydroxymethyl)phenol | HCID 10606838 | — |
| 反応物 | Triphenylphosphonium hydrobromide | HCID 22178555 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (5-Fluoro-2-hydroxybenzyl)(triphenyl)phosphonium bromide | HCID 86638793 | — |
反応手順
In 186 ml of acetonitrile, 18.6 g (130.87 mmol) of 4-fluoro-2-(hydroxymethyl)phenol and 42.67 g (124.32 mmol) of triphenylphosphonium hydrobromide are stirred under reflux for 3 h. After cooling, the precipitate formed is filtered off with suction and dried. This gives 58 g (124 mmol, 100% of theory) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07985876B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-76c9457c1212430b9ee04f3077ce7db9 |
| 出典メモ | uspto-grants-2011_07 |