反应详情

In 186 ml of acetonitrile, 18.6 g (130.87 mmol) of 4-fluoro-2-(hydroxymethyl)phenol and 42.67 g (124.32 mmol) of triphenylphosphonium hydrobromide are stirred under reflux for 3 h. After cooling, the precipitate formed is filtered off with suction and dried. This gives 58 g (124 mmol, 100% of theory) of the title compound.

1. temperatureunder reflux for 3 h
2. temperatureAfter cooling
3. customthe precipitate formed
4. filtrationis filtered off with suction
5. customdried