tert-butyl (3S,4S)-3-(benzylamino)-4-hydroxypyrrolidine-1-carboxylate → 1-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine

HRID 1015959ノート

反応式

HRID 1015959 の反応式
C([NH:8][C@@H:9]1[C@@H:13]([OH:14])[CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[NH2:8][C@@H:9]1[C@@H:13]([OH:14])[CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10]1

参加物

4

反応物 1

HCID 11277777tert-butyl (3S,4S)-3-(benzylamino)-4-hydroxypyrrolidine-1-carboxylate

生成物 1

HCID 104654571-Boc-(3S,4S)-3-amino-4-hydroxypyrrolidine収率 98.9%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A solution of the intermediate (5.4 g, 18.5 mmol) of step B, Pd(OH)2/C (0.3 g) in MeOH (200 mL) was stirred under hydrogen at 55 psi overnight. The catalyst was filtered off and the filtrate was concentrated to give 3.7 g of the desired product as a solid. MS calculated (M+H)+ 203. found 203.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-8d883bf8168c452aafb0c95313c85e4e
出典データセット
uspto-grants-2011_07
特許番号
US07985730B2

反応ノート

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