Formic Acid → 4-(4-Oxocyclohexyloxy)-3-methoxy-2-methylpyridine
反応式
CC1(C)CO[C:5]2([CH2:12][CH2:11][CH:10]([O:13][C:14]3[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[C:15]=3[O:21][CH3:22])[CH2:9][CH2:8]2)[O:4]C1.C(O)=O>CC(C)=O>[O:4]=[C:5]1[CH2:8][CH2:9][CH:10]([O:13][C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[C:15]=2[O:21][CH3:22])[CH2:11][CH2:12]1参加物
4
実験手順
1 g of 4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-yloxy)-3-methoxy-2-methylpyridine is stirred with 20 ml of formic acid and 5 ml of acetone for 5 hours. The residue which remains after concentrating is purified by chromatography on silica gel using ethyl acetate. 0.3 g=41%; m.p.: 56° to 57° C.
後処理
- concentrationafter concentrating
- customis purified by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-91ac38e1cd644fcdbb0f2037b7004087
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723450
反応ノート
読み込み中…