Formic Acid → 4-(4-Oxocyclohexyloxy)-3-methoxy-2-methylpyridine

HRID 1016

反応式

HRID 1016 の反応式
CC1(C)CO[C:5]2([CH2:12][CH2:11][CH:10]([O:13][C:14]3[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[C:15]=3[O:21][CH3:22])[CH2:9][CH2:8]2)[O:4]C1.C(O)=O>CC(C)=O>[O:4]=[C:5]1[CH2:8][CH2:9][CH:10]([O:13][C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[C:15]=2[O:21][CH3:22])[CH2:11][CH2:12]1

参加物

4

反応物 2

HCID 284Formic AcidHCID 196939344-(3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-yloxy)-3-methoxy-2-methylpyridine

生成物 1

HCID 196940314-(4-Oxocyclohexyloxy)-3-methoxy-2-methylpyridine

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

1 g of 4-(3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-yloxy)-3-methoxy-2-methylpyridine is stirred with 20 ml of formic acid and 5 ml of acetone for 5 hours. The residue which remains after concentrating is purified by chromatography on silica gel using ethyl acetate. 0.3 g=41%; m.p.: 56° to 57° C.

後処理

  1. concentrationafter concentrating
  2. customis purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-91ac38e1cd644fcdbb0f2037b7004087
出典データセット
uspto-grants-1998_03
特許番号
US05723450

関連ノート

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