Hydrochloric Acid → 3-[2-(Dibutylamino)ethylamino]-1-nonyl-pyrrolidine-2,5-dione

HRID 1016524ノート

反応式

HRID 1016524 の反応式
[CH2:1]([N:10]1[C:14](=[O:15])[CH:13]=[CH:12][C:11]1=[O:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C(N(CC)CC)C.[CH2:24]([N:28]([CH2:32][CH2:33][CH2:34][CH3:35])[CH2:29][CH2:30][NH2:31])[CH2:25][CH2:26][CH3:27].Cl>C(#N)C.C(OCC)(=O)C>[CH2:24]([N:28]([CH2:32][CH2:33][CH2:34][CH3:35])[CH2:29][CH2:30][NH:31][CH:13]1[CH2:12][C:11](=[O:16])[N:10]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[C:14]1=[O:15])[CH2:25][CH2:26][CH3:27]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 77062N,N-DibutylethylenediamineHCID 512831N-Nonylmaleimide

生成物 1

HCID 5128573-[2-(Dibutylamino)ethylamino]-1-nonyl-pyrrolidine-2,5-dione

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 8857Ethyl Acetate溶媒

実験手順

N-nonyl maleimide (0.02 mM) prepared as described in Example 12 above in 2 ml of acetonitrile was treated with one equivalent of triethylamine and one equivalent of N,N-dibutylethylenediamine. The reaction mixture was stirred for six hours and then the acetonitrile was evaporated. The residue obtained was treated with cold aqueous dilute hydrochloric acid solution and ethyl acetate, with stirring for one hour. The ethyl acetate layer was then separated and concentrated to give the desired product.

後処理

  1. customthe acetonitrile was evaporated
  2. customThe residue obtained
  3. stirringwith stirring for one hour
  4. customThe ethyl acetate layer was then separated
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-d2a58ec7360943a4acba299008de7e77
出典データセット
uspto-grants-2002_11
特許番号
US06476053B1

反応ノート

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